실국밥무지하게 [1102291] · MS 2021 · 쪽지

2022-02-26 18:04:56
조회수 253

논문 공유 2

게시글 주소: https://orbi.kr/00055121851

Accorsi EK, Britton A, Fleming-Dutra KE, et al. Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants. JAMA. 2022;327(7):639–651. doi:10.1001/jama.2022.0470


Key Points

Question  What is the association between 3 doses of mRNA COVID-19 vaccine and symptomatic SARS-CoV-2 infection with the Omicron and Delta variants?


Findings  In this test-negative case-control analysis that included 70 155 tests from symptomatic adults, the likelihood of vaccination with 3 mRNA vaccine doses (vs unvaccinated) was significantly lower among both Omicron (odds ratio, 0.33) and Delta (odds ratio, 0.065) cases than SARS-CoV-2–negative controls; a similar pattern was observed with 3 vaccine doses vs 2 doses (Omicron odds ratio, 0.34; Delta odds ratio, 0.16).


Meaning  These findings suggest that vaccination with 3 doses of mRNA COVID-19 vaccine, compared with being unvaccinated and with receipt of 2 doses, was associated with protection against both the Omicron and Delta variants, although higher odds ratios for the association with Omicron infection suggest less protection for Omicron than for Delta.


이 논문에서의 odds는 걸린 사람의 수를 안 걸린 사람의 수로 나눈 비라고 보시면 됩니다.

그러니까 3 vaccine doses vs 2 doses에서의 odds ratio는

(3차 맞고 걸린 사람/3차 맞고 안 걸린 사람)/(2차 맞고 걸린 사람/2차 맞고 안 걸린 사람)을 의미하며,


오즈비는 원래 상대위험도(걸릴 위험의 비가 얼마인가)와 다른 수치이지만 몇몇 요건이 만족되면 상대위험도의 근사치 정도로 취급될 수 있습니다.

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