환장할 고3의 논문읽기

현역 고3인데

논문 많이 읽긴 함

세특떔에

근데 논문중에 어떤거 많이 읽냐?

유전자의 발현이 정신질환에 어떤 영향을 끼치는가와 관련된 논문 읽음

예전에 중딩때 많이 읽어서 그런가

딱히 역하진 않은데

어려움

예를 들자면

Epigenetic regulation in major depression and other stressrelated disorders: molecular mechanisms, clinical relevance and therapeutic potential이라는 논문인데 혼자서 해석해봄

참고로 아래는 개요임

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood. The heritability estimate of MDD is 30–40%, suggesting that genetics alone do not account for most of the risk of major depression. Another factor known to associate with MDD involves environmental stressors such as childhood adversity and recent life stress. Recent studies have emerged to show that the biological impact of environmental factors in MDD and other stress-related disorders is mediated by a variety of epigenetic modifications. These epigenetic modification alterations contribute to abnormal neuroendocrine responses, neuroplasticity impairment, neurotransmission and neuroglia dysfunction, which are involved in the pathophysiology of MDD. Furthermore, epigenetic marks have been associated with the diagnosis and treatment of MDD. The evaluation of epigenetic modifications holds promise for further understanding of the heterogeneous etiology and complex phenotypes of MDD, and may identify new therapeutic targets. Here, we review preclinical and clinical epigenetic findings, including DNA methylation, histone modification, noncoding RNA, RNA modification, and chromatin remodeling factor in MDD. In addition, we elaborate on the contribution of these epigenetic mechanisms to the pathological trait variability in depression and discuss how such mechanisms can be exploited for therapeutic purposes. 

요약하자면..

MDD가 우을증 비슷한건데, 아직 원인이 명확하게 밝혀지진 않음. 실제로 유전자만 가지고 우울증을 설명할수도 없고, 여러가지 있음. 어린시절의 불우함이나, 아니면 뭐 최근에 스트레스 줜나 받았거나..그런게 많은데

이런 후생적인것들이 신경학적으로 존나 부정적인 영향을 끼침.

근데 이 후생적인 것들이 MDD의 치료나 발병원인과 상당히 관련이 있음. 그래서 우리가 이거와 관련된 매커니즘 등등과, 추가적으로 이 매커니즘이 어떤 영향을 끼치는지와 관련해서 자세하게 파헤쳐볼려고 함.

이라는 내용같은데

아 너무 어렵다

이걸 의대에서 한다고?

어우..